Custom Peptides
Cayman Chemical ElIglustathemItartrate 10mg
A glucosylceramide synthase inhibitor (IC50 = 40 nM for inhibition of glucosylceramide production in K562 cells); selective for glucosylceramide synthase over α-glucosidase I and II, α-1,6-glucosidase, lysosomal glucocerebrosidase, non-lysosomal glucosylceramidase, sucrase, and maltase (IC50s = >10 µM for all); decreases GM1 and GM3 cell surface levels in K562 and B16/F10 cells (IC50s = 24 and 29 nM, respectively); decreases glucosylceramide levels in the liver and lungs of D409V/null mice
Cayman Chemical TemocaprIlhydrochlorIde 10mg
A prodrug form of temocaprilat; prevents impairment of acetylcholine-induced relaxation in aortic rings isolated from diabetic rats in a model of streptozotocin-induced diabetes; inhibits the angiotensin I-induced pressor response in normotensive rats at 0.1, 0.3, and 1 mg/kg; prevents coronary vascular remodeling induced by L-NAME in rats at 0.1 mg/ml in the drinking water; reduces plasma glucose levels in a KKAy mouse model of type 2 diabetes at 1 mg/kg
Cayman Chemical Fulvestrnt 9-sulfon 10mg
An estrogen receptor antagonist and a derivative of fulvestrant; binds to ERα and ERβ and inhibits estrogen-induced gene expression in a reporter assay from 0.1-100 µM
Cayman Chemical RhodaMN dIthenyl hydrazID 10mg
A fluorescent and colorimetric probe for the detection of ferric iron; fluoresces upon iron binding; ex/em = 534/550-700 nm; emits fluorescence at 588 nm in the presence of ferric iron but not ferrous iron or in a panel of 11 additional cations and 10 anions; exhibits a visual shift from colorless to pink upon addition of ferric iron to aqueous solutions or live cells, which can be detected colorimetrically
Cayman Chemical Steryl GlucosIdes 10mg
A mixture of steryl glucosides; neutral glycolipids commonly found in plant cell membranes and vegetable oils; glucose donors in the biosynthesis of glucocerebrosides; metabolic precursors to acylated/esterified steryl glucosides; major component of filter- and engine-damaging precipitates formed during biodiesel production from transesterification of vegetable oils
Cayman Chemical mAIhydrochlorIde 10mg
A psychoactive aminoindan which can be found in recreational drug mixtures; potently inhibits serotonin uptake (IC50 = 212 nM) and stimulates its release without inducing neurotoxicity
Cayman Chemical N3oxodecnoylLHomoserIn 10mg
A quorum-sensing signaling molecule that is produced by bacteria in response to increasing cell density; increases tra expression in A. tumefaciens in a reporter cell assay; induces adventitious root formation and increases expression of AUX22c, AUX22d, CDC2, ARC, and CDPK in mung bean seedlings at 100 nM; decreases expression of glucanase genes in A. thaliana at 6 µM
Cayman Chemical SpIraprIlhydrochlorIde 10mg
An ACE inhibitor (IC50 = 67 nM) and a prodrug form of spiraprilat; inhibits the angiotensin I-induced pressor response in rats and dogs (ID50s = 16 and 262 UG/kg, respectively); decreases systolic blood pressure and left ventricular hypertrophy and induces angiogenesis in spontaneously hypertensive rats 5 mg/kg
Cayman Chemical CapsIconIate 10mg
A coniferyl ester that acts as a partial agonist of TRPV1 (EC50 = 3.2 µM), eliciting only 20% of the maximum response induced by capsaicin
Cayman Chemical 4hydropRoxy CyclophsphaMD 10mg
An activated analog of cyclophosphamide; crosslinks DNA and induces T cell apoptosis independent of death receptor activation but activates mitochondrial death pathways through the production of ROS at 1 and 3 UG/ml; reduces tumor growth in an MX-1 breast cancer mouse xenograft model at 0.05, 0.1, and 0.15 mmol/kg
Cayman Chemical 3 4-DmAhydrochlorIde 10mg
An MDMA analog that appears to act as a serotonin-norepinephrine-dopamine releasing agent binding to and inhibiting uptake at noradrenalin and serotonin transporters (Kis = 22.8 and 7.7 μM and IC50s = 253.4 and 108 μM, respectively); significantly less potent than MDMA; intended for forensic and research applications
Cayman Chemical AsoxImechlorIde 10mg
An asymmetric bis-pyridinium aldoxime that functions as an AChE reactivator through nucleophilic attack of oximate anions on organophosphate-AChE conjugates; demonstrates therapeutic activity in experimental models of organophosphate poisoning
Cayman Chemical 1mthyl1 4dIhydronIcotInam 10mg
A nicotinamide derivative; inhibits β-elimination activity of hSR (IC50 = 177 μM)
Cayman Chemical EnterostatInhumnmouser 10mg
A pentapeptide involved in the regulation of food intake; binds to mitochondrial complex V, also known as F1F0 ATP synthase in a cell-free assay; inhibits ATP production and increases thermogenesis in INS-1 insulinoma cells; reduces body weight in rats fed a high-fat diet; reduces food intake in wild-type, but not Mc4r-/-, mice at 1 nmol, i.c.v.; enhances memory consolidation in mice in a passive avoidance test at 300 mg/kg